Under contruction

Peer-reviewed Publications

1. Skinner TS, Manning LS, Johnston WA & Davis TME. In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs. International Journal for Parasitology, 1996 26(5): 519-525. Citations = 94.

2. Skinner-Adams TS, Davis TME, Manning LS & Johnston WA. The efficacy of benzimidazole drugs against Plasmodium falciparum in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1997 91(5): 580-584. Citations = 32.

3. Davis TME, Skinner-Adams TS & Beilby J. In vitro growth inhibition of Plasmodium falciparum by retinol at concentrations present in normal human serum, Acta Tropica, 1998, 69(2):111-119.

4. Skinner-Adams T, Davis TME & Beilby J. Inhibition of growth in vitro of Plasmodium falciparum by vitamin E. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1998, 92(4): 467-468.

5. Skinner-Adams T & Davis TME. Synergistic in vitro antimalarial activity of omeprazole and quinine. Antimicrobial Agents and Chemotherapy, 1999, 43(5): 1304-1306.

6. Skinner-Adams T, Barrett H & Davis TME. Heterogeneous activity in vitro of vitamin A (retinol) in combination with novel and established antimalarial drugs. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1999, 93(5): 550-551. Citations = 14.

7. Hamzah J, Skinner-Adams T & Davis TME. In vitro antimalarial activity of trovafloxacin, a fourth-generation fluoroquinolone. Acta Tropica, 2000, 74(1): 39-42. Citations = 17.

8. Bezabih M, Abegaz BM, Dufall K, Croft K, Skinner-Adams T, Davis TME. Anti-plasmodial and antioxidant isofuranonaphthoquinones from the roots of Bulbine capitata. Planta Medica, 2001, 67(4): 340-344. Citations = 33.

9. Geoghegan DS, Skinner-Adams T, Davis TME. Plasmodium falciparum: isolate specific radiosensitivity. Experimental Parasitology, 2001, 99(2): 108-110. Citations = 4.

10. Skinner-Adams TS, Lawrie PM, Hawthorne PL, Gardiner DL, Trenholme KR. Comparison of Plasmodium falciparum transfection methods. Malaria Journal, 2003, 2, 19. Citations = 14.

11. Hamzah J, Skinner-Adams TS, Davis TME. In vitro antimalarial activity of retinoids and the influence of selective retinoic acid receptor antagonists. Acta Tropica, 2003, 87(3): 345-353. Citations = 24.

12. Skinner-Adams TS, Hawthorne PL, Trenholme KR, Gardiner DL. GATEWAY vectors for Plasmodium falciparum transfection. Trends in Parasitology, 2003, 19(1): 17-18. Citations = 11.

13. Gardiner DL, Skinner-Adams TS, Spielmann T, Trenholme KR. Malaria transfection and transfection vectors. Trends in Parasitology, 2003, 19(9): 381-383. Citations = 24.

14. Gardiner DL, Spielmann T, Dixon MWA, Hawthorne PL, Ortega MR, Anderson KL, Skinner-Adams TS, Kemp DJ, Trenholme KR. CLAG 9 is located in the rhoptries of Plasmodium falciparum. Parasitology Research, 2004, 93(1): 64-7. Citations = 29.

15. Hamzah J, Davis TME, Skinner-Adams TS, Beilby J. Characterization of the effect of retinol on Plasmodium falciparum in vitro. Experimental Parasitology, 2004, 107(3-3): 136-44. Citations = 23.

16. Hawthorn PL, Trenholme KR, Skinner-Adams TS, Spielmann T, Fischer K, Dixon MWA, Ortega MR, Anderson KL, Kemp DJ, Gardiner DL. A Novel Plasmodium falciparum Ring Stage Protein, REX is Located in Maurers Clefts. Molecular and Biochemical Parasitology, 2004, 136(2): 181-189. Citations = 71.

17. Skinner-Adams TS. McCarthy JS, Gardiner, JS, Andrew KT. Antiretrovirals as antimalarial agents. Journal of Infectious Diseases, 2004, 190(11): 1998-2000. Citations = 120

18. Gardiner DL, Dixon MWA, Spielmann T, Skinner-Adams TS, Hawthorne PL, Ortega MR, Kemp DJ, Trenholme KR. Implication of a Plasmodium falciparum gene in the switch between asexual reproduction and gametocytogenesis. Molecular and Biochemical Parasitology, 2005, 140(2):153-60. Citations = 28.

19. Skinner-Adams TS. Guddat LW, Gardiner DL, McCarthy JS Andrews KT. Are Plasmodium falciparum plasmepsin’s the target of HIV proteases? Journal of Infectious Diseases, 2005. 191(8): 1382-1383. Citations = 5.

20. Andrews KT, Fairlie DP, Madala PK, Ray J, Wyatt DM, Hilton PM, Melville LA, Beattie L, Gardiner DL, Reid RC, Stoermer MJ, Skinner-Adams TS, Berry C, McCarthy JS. Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria. Antimicrobial Agents and Chemotherapy, 2006, 50(2): 639-648. Citations = 110.

21. Gardiner DL, Trenholme KR, Skinner-Adams TS, Stack CM and Dalton JP. Over-expression of Leucyl aminopeptidase in Plasmodium falciparum parasites: Target for the anti-malaria activity of Bestatin. Journal of Biological Chemistry, 2006, 281(3): 1741-1745. Citations = 49.

22. Keough DT, Skinner-Adams T, Jones MK, Ng A-L, Brereton IM, Guddat LW and de Jersey J. Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases. Journal of Medicinal Chemistry, 2006, 49(25): 7479-7486. Citations = 37.

23. Stack, CM, Lowther, J, Cunningham E, Donnelly S, Gardiner DL, Trenholme KR, Skinner-Adams TS, Teuscher F, Grembecka J, Mucha A, Kafarski P, Lua L, Bell A, Dalton JP. Characterisation of the Plasmodium falciparum M17 leucyl aminopeptidase: a protease involved in amino acid regulation with potential for antimalarial drug development. Journal of Biological Chemistry, 2007, 282(3): 2069-2080. Citations = 82.

24. Skinner-Adams TS, Andrews KT, Melville L, McCarthy J, Gardiner DL. Synergistic interactions of antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro. Antimicrobial Agents and Chemotherapy, 2007, 51(2): 759-762. Citations = 41.

25. Dunn LA, Andrews KT, McCarthy JS, Wright JM, Skinner-Adams TS, Upcroft P, Upcroft JA. The activity of protease inhibitors against Giardia duodenalis and metronidazole-resistant Trichomonas vaginalis. International Journal of Antimicrobial Agents. 2007, 29(1): 98-102. Citations = 21.

26. Redmond AM, Skinner-Adams T; Andrews, KT, Gardiner, DL; Ray J; Kelly M, McCarthy, JS. Antimalarial activity of sera from subjects taking HIV protease inhibitors. AIDS, 2007, 21 (6): 763-765. Citations = 29.

27. Andrews KT, Gatton ML, Skinner-Adams TS, McCarthy JS, Gardiner DL. HIV-malaria interactions: don't forget the drugs. Science. 2007, 315(5820):1791. Citations = 8.

28. Teuscher F, Lowther J, Skinner-Adams TS, Spielmann T, Dixon MWA, Stack CM, Donnelly S, Mucha, Kafarski P, Vassiliou S, Gardiner DL, Dalton JP, Trenholme KR. The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum. Journal of Biological Chemistry, 2007, 282(42): 30817-30826. Citations = 35.

29. Skinner-Adams TS, Lowther J, Teuscher F, Stack CM, Grembecka J, Mucha M, Kafarski P, Trenholme KR, Dalton JP, Gardiner DL. Identification of phosphinate analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidases as lead antimalarial compounds. Journal of Medicinal Chemistry, 2007, 50(24): 6024-6031. Citations = 53.

30. Andrews KT, Tran, TN, Lucke AJ, Kahnberg P, Le GT, Boyle GM, Gardiner DL, Skinner-Adams TS & Fairlie DP. Potent antimalarial activity of histone deacetylase inhibitor analogues. Antimicrobial Agents and Chemotherapy. 2008, 52(4):1454-1461. Citations = 74.

31. Skinner-Adams TS, Gardiner DL, McCarthy J, Andrew KT. HIV and malaria coinfection: interactions and consequences of chemotherapy. Trends in Parasitology, 2008, 24(6): 264-271. Citations = 64.

32. Lek-Uthai U, Suwanarusk R, Ruengweerayut R, Skinner-Adams TS, Nosten F, Gardiner DL, Boonma P, Piera K, Andrews KT, MacHunter B, McCarthy JS, Anstey NM, Price RN & Russell B. Stronger activity of human immunodeficiency virus type 1 protease inhibitors against clinical isolates of Plasmodium vivax than against those of P. falciparum. Antimicrobial Agents and Chemotherapy, 2008, 52(7): 2435-2441. Citations = 25.

33. McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly S, Grembecka J, Mucha A, Kafarski P, Buckle AM, Gardiner DL, Whisstock JC & Dalton JP. Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral. aminopeptidase: a new route for antimalarial compounds. PNAS 2009 106(8): 2537-42. Citations = 76

34. Maric S, Donnelly SM, Robinson MW, Skinner-Adams T, Trenholme KR, Gardiner DL, Dalton JP, Stack CM, Lowther J. The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors. Biochemistry. 2009 Jun 16;48(23):5435-9. Citations = 28.

35. Keough DT, Hocková D, Holý A, Naesens LM, Skinner-Adams TS, Jersey J, Guddat LW. Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4391-9. Citations = 63.

36. Brentlinger PE, Behrens CB, Micek MA, Steketee RW, Andrews KT, Skinner-Adams TS, Gardiner DL, McCarthy JS, Parikh S, ter Kuile F, Ayisi J. Plagiarism. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2009 103(8):855. Citations = 5.

37. Peatey CL, Skinner-Adams TS, Dixon MWA, McCarthy JS, Gardiner DL, Trenholme KR. The effect of antimalarial drugs on Plasmodium falciparum gametocytes. Journal of Infectious Diseases. 2009 (10): 1518-1521. Citations = 52.

38. Gardiner DL, Skinner-Adams TS, Brown CL, Andrews KT, Stack C, McCarthy JS, Dalton JP, and Trenholme KR. Plasmodium falciparum: new molecular targets with potential for anti-malarial drug development. Expert Review of Anti-infective Therapy 2009 7(9):1087-98. Citations = 17.

39. Skinner-Adams TS, Stack CM, Trenholme KR, Brown CL, Grembecka J, Lowther J, Mucha A, Drag M, Kafarski P, McGowan S, Whisstock JC, Gardiner DL & Dalton DP. Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials. Trends in Biochemical Sciences. 2010 35(1):53-61. Citations = 66.

40. Peatey CL, Andrews KT, Eickel N, Macdonald T, Butterworth AS, Trenholme KR, Gardiner DL, McCarthy JS and Skinner-Adams TS. Antimalarial asexual stage-specific and gametocytocidal activity of HIV protease inhibitors. Antimicrobial Agents and Chemotherapy. 2010 54(3): 1334-7. Citations = 25.

41. McGowan S, Oellig CA, Birru WA, Caradoc-Davies TT, Stack CM, Lowther J, Skinner-Adams T, Mucha A, Kafarski P, Grembecka J, Trenholme KR, Buckle AM, Gardiner DL, Dalton JP and Whisstock JC. Structure of the Plasmodium falciparum M17 aminopeptidase. Significance for the design of drugs targeting the neutral exopeptidases. PNAS 2010 107(6):2449-54. Citations = 42.

42. Trenholme K, Brown CL, Skinner-Adams TS, Stack C, Lowther J. To J, Robinson MW, Donnelly SM, Dalton JP and Gardiner DL. Aminopeptidases of malaria parasites: new targets for chemotherapy. Infect Disord Drug Targets. 2010 Jun; 10(3):217-25. Citations = 16.

43. Porter KA, Cole SR, Eron, JJ, YuZheng, Hughes MD, Lockman S, Poole C, Skinner-Adams TS, Hosseinipour M, Shaffer D, D’Amico R, Sawe FK, Siika A, Stringer E, Currier JS, Chipato T, Salata R, McCarthy JS and Meshnick SR. HIV-1 protease inhibitors and clinical malaria: A secondary analysis of ACTGA5208. Antimicrobial Agents and Chemotherapy. 2011 56(2): 995-1000. Citations = 11.

44. Poreba M, McGowan, S., Skinner-Adams, TS, Trenholme KR, Gardiner DL, Whisstock, JC To J, Dalton JP, Salvesen GS, Drag M. Fingerprinting the substrate specificity of M1 and M17 neutral aminopeptidases of human malaria, Plasmodium falciparum, using a novel fluorogenic substrate library. PLOS One. 7(2):e31938. 2012. Citations = 21.

45. Thivierge K, Mathews RT, Nsangou DMM, Da Silva F, Cotton S, Skinner-Adams TS, Trenholme KR, Brown CL, Gardiner DL, Dalton JP. Anti-malaria drug development targeting the M1 alanyl aminopeptidases and M17 leucyl aminopeptidases. Arkivoc. 2012 2012(4): 330-346. Citations = 1

46. Skinner-Adams T, C Peatey, K Anderson, K Trenholme, D Krige, C Brown, C Stack, D Nsangou, R Mathews, K Thivierge, J Dalton, and D Gardiner. The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria. Antimicrobial Agents and Chemotherapy.2012 56(6): 3244-9. Citations = 14.

47. Skinner-Adams TS, Butterworth AS, Porter KA, D’Amico R, Sawe S, Shaffer D, Siika A, Hosseinipour MC, Stringer E, Currier JS, Chipato T, Salata R, Lockman S, Eron JJ, Meshnick SR and McCarthy JS. The frequency of malaria is similar among women receiving either lopinavir/ritonavir or nevirapine-based antiretroviral treatment. PLOS One, 2012;7(4):e34399. doi: 10.1371/journal.pone.0034399. Epub 2012 Apr 3. Citations = 8.

48. Martin RE, Butterworth AS, Gardiner DL, Kirk, K, McCarthy JS and Skinner-Adams TS. Saquinavir inhibits PfCRT-mediated chloroquine transport. Antimicrobial Agents and Chemotherapy. 2012. 56(5):2283-9. Citations =12.

49. Sumanadasa S, Goodman C, Lucke A, Skinner-Adams T, Sahama I, Haque A, D Tram, McFadden G, Fairlie D, and Andrews K. Anti-malarial activity of the anti-cancer HDAC inhibitor SB939. Antimicrobial Agents and Chemotherapy. 2012. 56(7):3849-56. Citations = 30.

50. Mudanata W, Skinner-Adams T, Andrews K, Davis R, Hadi T, Hayes P and Garson M. Psammaplysin derivatives from the Balinese marine sponge Aplysinella strongylata. Journal of Natural Products. 2012. 75(12) 2132-43.Citations = 9.

51. Schoenen FJ, Weiner WS, Baillargeon P, Brown CL, Chase P, Ferguson J, Fernandez-Vega1 V, Ghosh P, Hodder P, Krise JP, Matharu DS, Neuenswander B, Porubsky, P, Rogers S, Skinner-Adams T, Sosa M, Spicer T, To J, Tower NA, Trenholme KR, Wang J, Whipple D, Aubé J, Rosen H, White E, Dalton JP and Gardiner DL. Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase. Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.2013 Apr 15 [updated 2013 Nov 14]. Citations = 1.

52. Butterworth AS, Skinner Adams TS, Gardiner DL, Trenholme KR. (2013) Plasmodium falciparum gametocytes: with a view to a kill. Parasitology. 140(14) 1718-34. Citations = 4.

53. Hoan V, Roullier C, Campitelli M, Trenholme K, Gardiner DL, Andrews KT, Skinner-Adams TS, Crowther G, Van Voorhis W and Quinn R. (2013). Plasmodium Gametocyte Inhibition identified from a Natural Product-Based Fragment Library. ACS Chemical Biology 8(12):2654-9. Citations = 7.

54. Andrews KT, Fisher GM, Sumanadasa SD, Skinner-Adams T, Moeker J, Lopez M, Poulsen SA. (2013) Antimalarial activity of compounds comprising a primary benzene sulfonamide fragment. Bioorg Med Chem Lett. 2013 Nov 15; 23(22):6114-7. Citations = 3.

55. Hansen FK, Skinner-Adams TS, Duffy S, Marek L, Sumanadasa SDM, Kuna K, Mordmüller B, Avery VM, Andrews KT and Kurz T. (2014) Synthesis, antimalarial properties and SAR studies of alkoxyurea-based HDAC inhibitors. Chem Med Chem 9(3):665-70. Citations = 5.

56. Pouwer RH, Deydier SM, Phuc Van Le, Schwartz BD, Franken NC, Davis RA, Coster MJ, Charman SA, Edstein MD, Skinner-Adams TS, Andrews KT, Jenkins ID, and Quinn RJ. (2013). Total synthesis of Thiaplakortone A: Derivatives as Metabolically Stable Leads for the Treatment of Malaria. ACS Med Chem. Lett. 5(2): 178-182 2013. Citations = 5.

57. Andrews KT, Fisher G and Skinner-Adams TS. Drug repurposing and human parasitic protozoan diseases. (2014). IJP Drugs Drug Resist. Invited Review. Mar 24; 4(2) 95-111. Citations = 30.

58. Spicer T, Fernandez-Vega V, Chase P, Scampavia L, To J, Dalton JP, Da Silva FL, Skinner-Adams TS, Gardiner DL, Trenholme KR, Brown CL, Ghosh P, Porubsky P, Wang JL, Whipple DA, Schoenen FJ, Hodder P. (2014). Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening. J Biomol Screen 19(7) 1107-1115. Citations = 1.

59. Raju R, Khalil Z, Piggott AM, Blumenthal A, Gardiner DL, Skinner-Adams TS and Capon RJ (2014). Mollemycin A: An antimalarial and antibacterial glycohexadepsipeptide-polyketide from an Australian marine derived Streptomyces sp. (CMB-M0244). Organic Letters. 16(6):1716-9. Citations = 2.

60. Trenholme KR, Marek L, Duffy S, Pradel G, Fisher G, Hansen FK, Skinner-Adams TS, Butterworth A, Ngwa CJ, Moecking J, Goodman C, McFadden G, Sumanadasa SDM, Fairlie D, Avery V, Kurz T & Andrews KT. (2014). Lysine acetylation in sexual stage malaria parasites is an epigenetic target for antimalarial small molecules. Antimicrobial Agents and Chemotherapy, 58(7):3666-3678. Citations = 9.

61 Schwartz BD, Skinner-Adams TS, Andrews KT, Coster MJ, Edstein MD, MacKenzie D, Charman SA, Koltun M, Blundell S, Campbell A, Pouwer RH, Quinn RJ, Beattie KD, Healy PC, Davis RA. (2015). Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold. Org Biomol Chem. 213, 1558-1570. Citations = 1.

62 Schoenen FJ, Whipple D, Baillargeon P, Brown CL, Chase P, Ferguson J, Fernandez-Vega V, Hodder P, Mathew R, Neuenswander B, Porubsky P, Rogers S, Skinner-AdamsT, Sosa M, Spicer T, To J, Tower NA, Trenholme KR, Wang J, Weiner WS, Aubé J, Rosen H, White EL, Gardiner DL, Dalton JP. Inhibitors of the Plasmodium falciparum M17 Leucine Aminopeptidase. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2013 Dec 12. Citations = 0.

63 White AM, Pierens GK, Skinner-Adams T, Andrews KT, Bernhardt PV, Krenske EH, Mollo E, Garson MJ. Antimalarial Isocyano and Isothiocyanato Sesquiterpenes with Tri- and Bicyclic Skeletons from the Nudibranch Phyllidia ocellata. J Nat Prod. 2015 Jun 26; 78(6):1422-7.

64 Schwartz BD, Coster MJ, Skinner-Adams TS, Andrews KT, White JM, Davis RA. (2015). Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A-D. Mar Drugs. 2015 Sep 15;13(9):5784-95 

65 Engle JA, Jones A, Avery VM, Sumanadasa SDM, Ng SS, Fairlie DP, Skinner-Adams TS & Andrews KT. Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites. Drugs and Drug resistance. Accepted for publication May 12 2015

66 Skinner-Adams TS, Sumanadasa SD, Fisher GM, Davis RA, Doolan DL, Andrews KT. Defining the targets of antiparasitic compounds. Drug Discov Today. 2016 Jan 16. pii: S1359-6446(16)00018-0. doi: 10.1016/j.drudis.2016.01.002. [Epub ahead of print].

67 Arnold MS, Engel JA, Chua MJ, Fisher GM, Skinner-Adams TS, Andrews KT. Adaption of the [3H]-hypoxanthine uptake assay for in vitro cultured Plasmodium knowlesi malaria parasites. 2016 Apr 25. AAC.02948-15. [Epub ahead of print] 

68 da Silva FL, Dixon MWA, Stack CM, Teuscher F, Taran E, Jones MK, Lovas E, Tilley L, Brown CL, Trenholme KR, Dalton JP, Gardiner DL & Skinner-Adams TS. A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability. Experimental Parasitology Accepted June 2016

69 Sauer, B., Skinner-Adams, T. S., Bouchut, A.,Chua, M. J., Pierrot, C., Erdmann, F., Robaa, D., Schmidt, M., Khalife, J.,Andrews, K. T., and Sippl, W. (2016) Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum. European Journal of Medicinal Chemistry 127, 22-40

70 Chua, M. J., Arnold, M. S., Xu, W., Lancelot, J., Lamotte, S., Spath, G. F., Prina, E., Pierce, R. J., Fairlie, D. P., Skinner-Adams, T. S., and Andrews, K. T. (2016) Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth. International Journal for Parasitology. Drugs and Drug Resistance 7, 42-50

71 Hart, C.J.S, Munro, T, Andrews, K. T., Ryan, J. H. Riches, A. G. and Skinner-Adams. T.S. (2017). A novel in vitro image-based assay identifies new drug leads for giardiasis. International Journal for Parasitology. Drugs and Drug Resistance 7, 42-50. In Press, Available online 27 January 2017. http://www.sciencedirect.com/science/article/pii/S2211320716301300